Steffi Oesterreich, PhD
Professor of Pharmacology and Chemical Biology
Director of Education, Women’s Cancer Research Center
Magee Women’s Research Institute
University of Pittsburgh Cancer Institute
The main interest of Dr. Oesterreich’s research is to further our understanding of hormone action in women’s cancer in order to use this knowledge for improved diagnosis and endocrine treatment. Her studies have focused on breast cancer and in receptor action in ovarian cancer. Her lab studies how the estrogen receptor (ER) functions, how its activity is regulated by diverse signaling pathways and through coregulator proteins, and if and how these mechanisms are perturbed in cancer cells. The Oesterreich lab is interested in novel concepts of ER action, such as its role in repression of gene transcription and its role in epigenetic marks in the genome. Dr. Oesterreich’s lab has also a strong interest in situ and invasive lobular disease, with a focus on estrogen and antiestrogen response. In her role as Director of Training in the Women’s Cancer Research Center, she is interested in providing outstanding training opportunities to the next generation of women’s cancer researchers.